Prescription animal remedy
 
 
Gastropell Daily

Oral paste for horses

Active constituent: Omeprazole 50mg/ml

For the treatment and prevention of the recurrence of gastric ulcers in horses.

Gastropell Daily contains omeprazole, a dose-dependant inhibitor of gastric acid secretion. Clinical trial data indicates that Gastropell Daily will inhibit gastric acid secretion to maintain gastric acidity at a non-aggressive level, which allows existing ulcers to heal within two weeks of commencing treatment, and that a reduced daily dose will prevent the recurrence of ulcers.

Actions
Omeprazole is an inhibitor of gastric acid secretion. When given on a daily basis, omeprazole inhibits the enzyme system regarded as the acid (proton) pump within the gastric mucosa of the stomach by binding to the enzyme and blocking the first step of acid production.

Even though it is dosed orally, Gastropell Daily does not act directly on the stomach fluid as it is ingested. The drug passes through the stomach to the small intestine, where it is absorbed and travels via the bloodstream to the acid secreting cells of the stomach.

The powerful antisecretory effect of Gastropell Daily causes a dramatic reduction in the acidity of the stomach fluid within days of commencing treatment, and because the gastric fluid is no longer irritating to the stomach lining, ulcers then heal spontaneously within two weeks. Continuation with reduced daily dosing the prevents ulcers from recurring.

 

Indications
The lower region of the stomach is permanently exposed to gastric acid and has a prostaglandin protective mechanism, which guards against acid attack.

The squamous mucosa in the upper region of the stomach has, however, no inherent protection and frequent splashing with gastric acid fluid soon erodes the lining to cause spot lesions, which can develop into deep haemorrhaging ulcers within weeks.

For the stabled performance of horse given two or three feeds a day, the stomach is left for long periods without ingestion of feed and without the mat of ingesta on the surface of the stomach fluid that helps to contain the acidic fluid. This exposure to acid is then increased during intense exercise when the stomach volume is reduced to half that of the rested horse and the gastric acid is forced into the squamous region where it attacks the stomach lining.

The stomach lining is in a continual process of erosion and repair depending on the acidity of the stomach fluid and the horse/s feeding and exercise patter.

The pattern of regular sessions of intense training and long periods of the day without ingestion of feed is, however, well tolerated by the performance horse in training if gastric acid secretion is blocked by Gastropell Daily – every day – and the gastric fluid is then not aggressive to the stomach lining.

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